Sega Mega Drive/Genesis — Games (S)

Saban's VR Troopers — NTSC-U

Sacred Line Genesis — NTSC-U

Sailor Moon — NTSC-J

Saint Sword — NTSC-J, NTSC-U, PAL

Sampras Tennis 96 — PAL

Samurai Shodown — NTSC-J, NTSC-U, PAL

Sangokushi Retsuden: Ransei no Eiyuu-tachi — NTSC-J

Sansan — NTSC-J

Sasha Darko's Sacred Line — NTSC-J, NTSC-U, PAL

Saturday Night Slam Masters — NTSC-U

Scholastic's The Magic School Bus: Space Exploration Game — NTSC-U

S.C.I.: Special Criminal Investigation — NTSC-J, NTSC-U

Scooby-Doo Mystery — NTSC-U

Scrabble — NTSC-J, NTSC-U, PAL

Seaquest DSV — NTSC-J, NTSC-U, PAL

Second Samurai — NTSC-J, NTSC-U, PAL

Sega Master System Brawl — NTSC-J, NTSC-U, PAL

Sega Soccer — PAL

Sega Sports 1 — PAL

Sega Sports NFL 98 — NTSC-J, NTSC-U, PAL

Sega Top Five — NTSC-U

Sega Top Ten — NTSC-U

Sesame Street Counting Cafe — NTSC-J, NTSC-U, PAL

Shadow Blasters — NTSC-J, NTSC-U, PAL

Shadow Dancer: The Secret of Shinobi — NTSC-J, NTSC-U, PAL

Shadow of the Beast — NTSC-U, PAL

Shadow of the Beast II — NTSC-J, NTSC-U, PAL

Shadowrun — NTSC-U

Shanghai II: Dragon's Eye — NTSC-J, NTSC-U, PAL

Shaolin Carcará — NTSC-J, NTSC-U, PAL

Shaq-Fu — NTSC-U, PAL

Sharks — NTSC-U

Sharpshooter — NTSC-J, NTSC-U, PAL

Shi-Kin-Joh — NTSC-J, NTSC-U, PAL

Shining Force — NTSC-J, NTSC-U, PAL

Shining Force II — NTSC-J, NTSC-U, PAL

Shining in the Darkness — NTSC-J, NTSC-U, PAL

Shinobi III: Return of the Ninja Master — NTSC-J, NTSC-U, PAL

Shogi no Hoshi — NTSC-J

Shootout — NTSC-U

Shove It! The Warehouse Game — NTSC-J

Show do Milhão — NTSC-U

Show do Milhão Volume 2 — NTSC-U

Shura no Mon — NTSC-J

Side Pocket — NTSC-J, NTSC-U, PAL

Sidewinder — NTSC-U

SimCity — NTSC-U

Skater — NTSC-U

Skeleton Krew — NTSC-U, PAL

Skeleton Scale — NTSC-U

Sketch — NTSC-U

Skirmish — NTSC-U

Skitchin' — NTSC-J, NTSC-U, PAL

Sky Avenger — NTSC-U

Slalom — NTSC-U

Slam Dunk: Kyougou Makkou Taiketsu! — NTSC-J

Slam: Shaq vs. The Legends — NTSC-J, NTSC-U, PAL

Slap Fight MD — NTSC-J, NTSC-U, PAL

Snake — NTSC-U

Snake Rattle 'n' Roll — NTSC-J, NTSC-U, PAL

Snowboarding — NTSC-U

Snow Bros.: Nick & Tom — NTSC-J

Socket — NTSC-J, NTSC-U

Socks the Cat Rocks the Hill — NTSC-U

Soldiers of Fortune — NTSC-U, PAL

Sol-Feace — NTSC-U

Solitaire In Space — NTSC-J, NTSC-U, PAL

Sonic 3D Blast — NTSC-U, PAL

Sonic Bash — NTSC-J, NTSC-U, PAL

Sonic Classics — NTSC-J, NTSC-U, PAL

Sonic Eraser — NTSC-J, NTSC-U, PAL

Sonic the Hedgehog — NTSC-J, NTSC-U, PAL

Sonic the Hedgehog 2 — NTSC-J, NTSC-U, PAL

Sonic the Hedgehog 3 — NTSC-U, PAL

Sonic the Hedgehog 3 & Knuckles — NTSC-J, NTSC-U, PAL

Sonic the Hedgehog 3 Limited Edition — NTSC-J, NTSC-U, PAL

Sonic the Hedgehog: Spinball — NTSC-J, NTSC-U, PAL

Sonic Zeta Overdrive — NTSC-J, NTSC-U, PAL

Sorcerer's Kingdom — NTSC-J, NTSC-U, PAL

Sorcerian — NTSC-J

Soul Edge Vs. Samurai Spirits — NTSC-J, NTSC-U, PAL

Space Harrier II — NTSC-J, NTSC-U, PAL

Space Hunter — NTSC-U

Space Invaders '91 — NTSC-J, NTSC-U, PAL

Sparkster: Rocket Knight Adventures 2 — NTSC-J, NTSC-U, PAL

Spatter — NTSC-J, NTSC-U, PAL

Speedball 2: Brutal Deluxe — NTSC-J, NTSC-U

Speed Boat — NTSC-U

Spider — NTSC-U

Spider-Man — NTSC-U

Spider-Man and the X-Men in Arcade's Revenge — NTSC-U, PAL

Spider-Man and Venom: Maximum Carnage — NTSC-U, PAL

Spidey — NTSC-U

Spiritual Warfare — NTSC-U

Spirou — PAL

Splatterhouse 2 — NTSC-J, NTSC-U, PAL

Splatterhouse 3 — NTSC-J, NTSC-U, PAL

Sport Games — NTSC-U

Sports Talk Baseball — NTSC-U

Spot Goes to Hollywood — NTSC-U, PAL

SRD: Super Real Darwin — NTSC-J

Star Ball — NTSC-U

Star Control — NTSC-J, NTSC-U, PAL

Star Cruiser — NTSC-J

Star Duel — NTSC-U

Star Evil — NTSC-U

Starflight — NTSC-U

Stargate — NTSC-U

Star Mobile — NTSC-J, NTSC-U, PAL

Star Odyssey — NTSC-J, NTSC-U, PAL

Star Trek: Deep Space Nine - Crossroads of Time — NTSC-U

Star Trek: The Next Generation - Echoes from the Past — NTSC-U

Steel Empire — NTSC-J, NTSC-U

Steel Talons — NTSC-J, NTSC-U, PAL

Steven Seagal Is The Final Option — NTSC-U

Stone Protectors — NTSC-J, NTSC-U, PAL

Stormlord — NTSC-U

Street Fighter II: Special Champion Edition — NTSC-J, NTSC-U, PAL

Street Racer — NTSC-U, PAL

Street Smart — NTSC-J, NTSC-U, PAL

Streets of Rage — NTSC-J, NTSC-U, PAL

Streets of Rage 2 — NTSC-J, NTSC-U, PAL

Streets of Rage 3 — NTSC-J, NTSC-U, PAL

Strider — NTSC-J, NTSC-U

Strider Returns — NTSC-U, PAL

Striker — NTSC-J, NTSC-U, PAL

Striker — PAL

Sub Terrania — NTSC-J, NTSC-U, PAL

Sudoku but it's on the MD — NTSC-J, NTSC-U, PAL

Sudoku Quiz — NTSC-U

Sunday Drive — NTSC-U

Sunset Riders — NTSC-J, NTSC-U, PAL

Super Airwolf — NTSC-J, NTSC-U, PAL

Super Baseball 2020 — NTSC-J, NTSC-U, PAL

Super Battleship — NTSC-U

Super Big 2 — NTSC-J, NTSC-U, PAL

Super Bubble Bobble MD — NTSC-J, NTSC-U, PAL

Super Byoon — NTSC-J, NTSC-U, PAL

Super Caesars Palace — NTSC-J, NTSC-U, PAL

Super Daisenryaku — NTSC-J

Super Donkey Kong 99 — NTSC-J, NTSC-U, PAL

Super Fantasy Zone — NTSC-J, PAL

Super Hang-On — NTSC-J, NTSC-U

Super High Impact — NTSC-J, NTSC-U, PAL

Super Hydlide — NTSC-J, NTSC-U

Super Jeopardy! — NTSC-J, NTSC-U, PAL

Super Kick-Off — NTSC-U, PAL

Super Locomotive — NTSC-J, NTSC-U, PAL

Superman — NTSC-U, PAL

Super Mario World 64 — NTSC-J, NTSC-U, PAL

Super Monaco GP — NTSC-J, NTSC-U, PAL

Super Noah's Ark 3D — NTSC-J, NTSC-U, PAL

Super Off Road — NTSC-U

Super Ping Pong — NTSC-J, NTSC-U, PAL

Super Real Basketball — NTSC-J, NTSC-U, PAL

Super Skidmarks — PAL

Super Smash T.V. — NTSC-U

Super Spin — NTSC-J, NTSC-U, PAL

Super Star Wars — NTSC-J, NTSC-U, PAL

Super Star Wars Holiday Special — NTSC-J, NTSC-U, PAL

Super Street Fighter II — NTSC-J, NTSC-U, PAL

Super Tank War — NTSC-J, NTSC-U, PAL

Super Thunder Blade — NTSC-J, NTSC-U, PAL

Super Volley Ball — NTSC-J, NTSC-U, PAL

Surging Aura — NTSC-J

Sweetsdigger — NTSC-J, NTSC-U, PAL

Switchblade — NTSC-J, NTSC-U, PAL

Sword of Sodan — NTSC-J, NTSC-U, PAL

Sword of Vermilion — NTSC-J, NTSC-U, PAL

Syd of Valis — NTSC-J, NTSC-U

Sylvester & Tweety in Cagey Capers — NTSC-U

Syndicate — NTSC-U, PAL